The research interests of the LBC mainly focus on the synthesis of novel modified nucleoside analogues with interesting properties and biological activities.
Modified nucleosides play an important role in antiviral and anticancer chemotherapy. It is noteworthy that 15% of anticancer agents and 55% of antiviral agents are related to nucleoside analogues. The last decades nucleosides with five-membered and six-membered carbohydrate moieties have been evaluated for their potential antiviral and anticancer properties and as building blocks in nucleic acid chemistry. Lately, considerable interest in, exomethylene, fluoro and fluorothionucleosides has been generated in order to find new antitumor, antiviral, or anti-HIV drugs with better selectivity and less immunosuppressive effects compared with known clinically used compounds. It is also noteworthy that unsaturated ketonucleosides have been established for their antineoplastic activity and immunosuppressive effects. Based on these considerations the research interest of the LBC mainly focuses on the synthesis and biological evaluation of novel nucleoside analogues with specific structural features in the sugar and base moieties, such as unsaturation, exomethylene, fluorine, sulfur, cyano and ethynyl functions.
Pyrrole ring has found a wide number of applications and is present in many natural products. It is used as an important skeleton in organic synthesis and is also utilized in other important fields, such as materials science, medicinal chemistry, and pharmacology. Especially, 2-oxopyrroles show versatility and they are important substructures in a variety of drugs, including products active against viral infections (HIV , influenza, cytomegalovirus), anticancer agents, and products active against microbiological diseases (bacterial or fungal). Pyrroles fused to other heterocyclic systems, such as quinoxalines, have been of particular interest, since quinoxaline derivatives constitute the basis of many insecticides, fungicides, herbicides, as well as being important in human health and as receptor antagonists. Based on these data, the research in the LBC also includes the synthesis of halogenated pyrroles and their corresponding quinoxaline analogues.